Thames Valley Police's festive crackdown on drink and drug-driving saw 347 arrests across the area.
That's a rise of almost 9% on the previous December.
The force worked with their neighbours in Hampshire on the month long-crackdown leading up to Christmas and New Year.
In Hampshire, 254 drivers were caught under the influence of alcohol or drugs in their system which is a 12.6% increase from last year’s total of 222.
Over three quarters of those drivers arrested were male, with the highest offending age group across the two force regions were aged 21 to 30, a considerable amount more than any other age group.
Sergeant Rob Heard, Roads Policing Joint Operations Unit for Thames Valley Police and Hampshire Constabulary, said:
“We’ve seen a rise in the number of people we have arrested for drink or drug-driving. New legislation and equipment has made detecting drug drivers much easier and this resulted in 63 extra arrests. 25% of those were impaired by drugs.
“Our commitment in roads policing is unwavering towards preventing the distress and misery caused by driving under the influence of drink or drugs.
“Such behaviour on our roads has far-reaching effects not just for the impaired driver, but for any innocent road users affected by their destructive decisions.
“The lives of individuals and their families can be torn apart through a combination of physical, psychological and legal consequences.
“Too many people continue to be complacent about the realities of road deaths and serious injuries. That’s why we want everyone to be clear about their responsibilities, and have respect for each other on the road.
“As in previous campaigns, we were greatly assisted by members of the public who passed us vital information and helped us take these drivers off the roads. Drink and drug-driving kills or injures people.
“Our message is simple – don’t mix drink or drugs with driving – it’s not worth the risk.”